Anti-mutum MMP-3 Antibody, Mouse Monoclonal

Janar bayani
Matrix metallopeptidase 3 (wanda aka rage a matsayin MMP3) kuma ana kiransa stromelysin 1 da progelatinase.MMP3 memba ne na dangin matrix metalloproteinase (MMP) wanda membobinsu ke da hannu a cikin rushewar matrix na waje a cikin tsarin ilimin halittar jiki na yau da kullun, kamar haɓakar amfrayo, haifuwa, gyaran nama, da hanyoyin cututtuka gami da amosanin gabbai da metastasis.A matsayin endopeptidase mai dogara da zinc da aka ɓoye, MMP3 yana aiwatar da ayyukansa musamman a cikin matrix extracellular.Ana kunna wannan furotin ta hanyar manyan inhibitors na endogenous guda biyu: alpha2-macroglobulin da masu hana nama na metalloproteases (TIMPs).MMP3 yana taka muhimmiyar rawa wajen lalata nau'ikan collagen II, III, IV, IX, da X, proteoglycans, fibronectin, laminin, da elastin.Har ila yau, MMP3 na iya aiki da wasu MMPs kamar MMP1, MMP7, da MMP9, yana mai da MMP3 mahimmanci a gyaran kyallen takarda.Dysregulation na MMPs an haɗa shi a cikin cututtuka da yawa da suka haɗa da amosanin gabbai, ulcers, encephalomyelitis, da ciwon daji.Masu hanawa na roba ko na halitta na MMPs suna haifar da hana metastasis, yayin da haɓaka tsarin MMPs ya haifar da haɓaka ƙwayar cutar kansa.