Anti- ɗan adam TIMP1 Antibody, Mouse Monoclonal

Janar bayani
TIMP metallopeptidase inhibitor 1, wanda kuma aka sani da TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating ayyuka, TPA-S1TPA-induced proteinTissue inhibitor na metalloproteinases 1, shi ne na halitta inhibitors na matrix metalloproteinases perientes. da hannu wajen lalata matrix na extracellular.Ana samun TIMP-1/TIMP1 a cikin kyallen jikin tayi da manya.Ana samun mafi girman matakan a cikin kashi, huhu, ovary da mahaifa.Complexes tare da metalloproteinases kuma ba tare da jujjuya su ba suna kashe su ta hanyar ɗaure su da cofactor na zinc.TIMP-1/TIMP1 yana magance erythropoiesis a cikin vitro;amma, ba kamar IL-3 ba, yana da takamaiman nau'in nau'in, yana ƙarfafa girma da bambance-bambancen kawai na ɗan adam da murine erythroid.Baya ga rawar da yake takawa akan mafi yawan sanannun MMPs, sunadaran suna iya haɓaka haɓakar tantanin halitta a cikin nau'ikan nau'ikan tantanin halitta, kuma yana iya samun aikin anti-apoptotic.Rubutun wannan kwayar halittar sunadaran sunada matukar wahala a mayar da martani ga cytokines da hormones da yawa.Bugu da kari, furucin daga wasu amma ba duka chromosomes marasa aiki na X suna nuna cewa wannan rashin kunnawar kwayoyin halitta shine polymorphic a cikin matan ɗan adam.Wannan nau'in halitta yana samuwa a cikin intron 6 na kwayar halittar synapsin I kuma an rubuta shi ta wata hanya dabam.Complexes tare da metalloproteinases kuma ba tare da jujjuya su ba suna kashe su ta hanyar ɗaure su da cofactor na zinc.TIMP-1/TIMP1 An san yana aiki akan MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 da MMP-16.